Fri Oct 24 2025

26 articles - From Friday Oct 17 2025 to Friday Oct 24 2025

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews

Inflamm Bowel Dis
Prevalence and Associated Factors of Nonalcoholic Fatty Liver Disease in Patients with Inflammatory Bowel Disease: An Updated Global Systematic Review and Meta-Analysis of over 1.5 Million Individuals.

NAFLD is a common comorbidity among patients with IBD, affecting over one in four individuals, with higher prevalence observed in adults, males, and certain geographic regions. Variation by diagnostic modality and disease location was also noted; however, these subgroup findings are based on limited data and should be interpreted with caution. Overall, the results highlight the importance of incorporating liver health screening into routine IBD management, particularly for high-risk populations, and underscore the need for future prospective studies to refine risk stratification and management strategies.

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Pancreas
Comparative Anatomy of Pancreas Across Animal Species: A Systematic Review.

This comparative review highlights the structural and histologic organization of the pancreatic tissue across animal species. This review offers a key resource for translational researchers seeking to develop animal models to recapitulate the spectrum of pancreatic disorders observed in human patients.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Am J Clin Nutr
Impact of Comprehensive Lifestyle Interventions on Plasma Branched-Chain Amino Acid Concentrations: A Randomized Trial.

Weight loss resulting from lifestyle interventions was associated with reductions in plasma BCAA concentrations. Improvements in fitness and diet composition were not associated with changes in BCAA concentrations independent of weight loss. Clinical trial registration

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Ultra processed food consumption by urbanization level among US youth and adults: Cross-Sectional Analysis of NHANES 2013-March 2020.

Adults in rural areas consumed more UPF and less MPF than those in urban areas in terms of both energy and grams. There were few significant differences by urbanization among youth.

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Inflamm Bowel Dis
Comparative Risk of Serious Infections Associated With Treatment of Inflammatory Bowel Disease.

In this nationwide IBD cohort, there was not an increased risk of infection-related hospitalization among patients exposed to vedolizumab, ustekinumab, and tofacitinib as compared with patients on anti-TNF inhibitor and TP combination therapy and rates of infection-related hospitalization were low overall. These findings should guide clinical decision making and patient-physician discussions when selecting a therapeutic agent with the primary emphasis on efficacy.

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Incidence and Natural History of Very Early-Onset Inflammatory Bowel Disease in Scotland: National and Regional Cohort Studies.

Scotland has a high incidence of VEOIBD, with monogenic IBD exceptionally rare. Although VEOIBD disease burden is high, treatment outcomes are broadly similar to those diagnosed later in childhood based on previous studies.

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Outcomes of Pouch Creation in 2-Stage Versus 3-Stage Procedures for Pediatric Ulcerative Colitis: A Propensity Score Matched Comparative Analysis.

This study demonstrated that surgical outcomes following pouch creation were similar in a matched cohort of children undergoing 2- or 3-stage IPAA, supporting the use of a 2-stage approach in certain patients with limited disease.

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Sexual Health Challenges in Individuals With and Without Inflammatory Bowel Disease: A Population-Based Study in Denmark.

Although the 5-item International Index of Erectile Function and 6-item Female Sexual Function Index scores did not indicate an excess of sexual dysfunction in the overall UC and CD populations, individuals with UC as well as patients with IBD experiencing active disease, stoma, or perianal involvement faced more sexual challenges than those without IBD. This highlights the need for gastroenterologists to proactively address sexual health and provide tailored support for patients with IBD.

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Xanthine Oxidase-Dependent Activation of NLPR3 Inflammasome in Epithelial Cells Sustains Inflammation in Inflammatory Bowel Disease.

and relevance Overexpression of XO in IBD might contribute to inflammation by promoting NLRP3 inflammasome activation and proinflammatory cytokine production.

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J Crohns Colitis
Anti-tumor necrosis factor treatment from diagnosis is more effective and less costly than conventional "step-up" care for patients with active Crohn's disease: a cost-effectiveness analysis from the PROFILE trial.

"Top-down" treatment from diagnosis with anti-TNF results in lower healthcare resource use and better clinical outcomes in patients with Crohn's disease compared to an "accelerated step-up" strategy.

Pubmed   Journal   ReadQx   PMC

Trends in Utilization of Advanced Therapies in Patients with Inflammatory Bowel Diseases in the USA, 2021-2025.

Contemporary trends in advanced therapy utilization in patients with IBD suggest an increased utilization of upadacitinib and anti-interleukins, accompanied by a decline in use of TNF antagonists in the U.S.

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Liver Transpl
Anonymous living donation expands access and enhances equity in pediatric liver transplantation: A retrospective cohort study.

Integrating anonymous non-directed donors enlarges the living-donor pool, decreases time to transplantation for vulnerable children, and preserves the superior long-term outcomes achieved with living-donor organs. Embedding A-LDLT alongside DDLT can reduce disparities and enable timely, life-saving transplantation for children without directed donors while maintaining the advantages associated with living-donor grafts.

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Long-term outcome of the initial cases with recipient-side minimal invasive liver transplantation: Single-center comparison study.

TLLT in adult is feasible and safe, achieving outcomes equivalent to open recipient surgery despite longer ischemic and operative times. Careful patient selection and technical refinements-potentially augmented by robotic assistance-may further optimize minimal invasive surgery for the recipient.

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Organ monitoring and identification of ischemic liver injury during ex situ porcine liver machine perfusion - a randomized controlled study.

Measurements taken in the hilar plate show the ability to identify bile duct damage while not introducing measurement devices to the vulnerable bile duct itself. Our findings enable more objective and timely selection of transplantable livers and warrant further investigation in clinical studies.

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Predictive value of controlled attenuation parameter in living liver donors for graft outcomes in corresponding recipients.

In conclusion, higher CAP values were associated with increased risk of SFSS and graft failure in LDLT recipients with GRWR <0.8%. Incorporating CAP into graft selection and pretransplant risk assessment may improve recipient outcomes, particularly when using small grafts in LDLT.

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Safety and feasibility of duct-to-duct biliary anastomosis in pediatric liver transplantation: A single-center retrospective study.

Appropriate learning and decision-making processes ensure the safety and feasibility of DDA, with excellent perioperative and long-term outcomes. It is therefore recommended that DDA should be considered the first choice for biliary reconstruction in eligible pediatric transplant patients.

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Pancreas
Silencing of SPI1/OLAH Axis Inhibits Pancreatic Acinar Cell Oxidative Stress, Inflammation and Apoptosis to Alleviate Hyperlipidemic Acute Pancreatitis.

SPI1-mediated transcriptional activation of OLAH promoted pancreatic acinar cell oxidative stress, inflammation and apoptosis to accelerate HAP progression.

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Pancreatology
Pancreatic cancer burden across Southeast Asia from 1990 to 2021: An analysis of incidence and mortality based on the global burden of disease study 2021.

The substantial rise in pancreatic cancer burden across Southeast Asia highlights the need for improved healthcare infrastructure, especially in lower-SDI countries. Regional collaboration and targeted interventions focusing on early detection, treatment access, and modifiable risk factors are crucial to reducing pancreatic cancer mortality. Strengthening healthcare systems and public health initiatives will be vital to address this growing regional and global health challenge.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

J Crohns Colitis
In response to jjaf121 adequacy of disclosures published July 2025.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Liver Transpl
Reframing hepatitis B prophylaxis in liver transplant recipients - time to focus on cure.

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The hemostatic cascade by viscoelastic testing in liver transplantation: Refining targets for possibly refined intervention.

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Pancreas
APA 2024 Business Meeting.

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Commentary on "Risk Factors for Early Liver Recurrence After Pancreatic Cancer Resection".

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Expanding the Framework of Decisional Control in IPMN Management.

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Understanding Patients' Desire for Decision Control in Treating IPMN: A Call for Future Research.

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Pancreatology
A cross-sectional study of liver dysfunction using transient elastography among patients with chronic pancreatitis.

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Letters&Replies

Letters to the editors and authors’ replies